Hif1an
WebHIF1AN is an asparaginyl hydroxylase enzyme that controls the transcriptional activity of hypoxia-inducible factor. FIH1 is a part of the Fe2+ and 2-oxoglutarate-dependent dioxygenase superfamily, FIH1 is protein that hydoxylates a specific asparagine residue (Asn-803) within the HIF1A C-terminal transactivation domain. WebHIF1AN/FIH-1 was immunoprecipitated from MCF7 (human breast adenocarcinoma cell line) whole cell lysate using ab237544 at 1/200 dilution. Lane 1: Rabbit control IgG in …
Hif1an
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WebFlow Cytometry analysis of HeLa (Human cervix adenocarcinoma epithelial cell) cells labeling HIF1AN/FIH-1 with purified ab92498 at 1/1000 dilution (1 µg/mL) (Red). Cells were fixed with 4% Paraformaldehyde and permeabilised with 90% Methanol. A Goat anti rabbit IgG (Alexa Fluor ® 488, ab150077) secondary antibody was used at 1/2000. Web8 de ago. de 2024 · HIF1AN was confirmed as a direct target of miR-135-5p. HIF1AN overexpression inhibited osteogenic differentiation and calcification while miR-135-5p reversed these effects. These results indicate that miR-135-5p might have a therapeutic application related to its promotion of bone formation through the targeting of HIF1AN.
WebInvitrogen Anti-HIF1AN Polyclonal, Catalog # PA5-117017. Tested in Western Blot (WB), Immunocytochemistry (ICC/IF) and Immunoprecipitation (IP) applications. This antibody reacts with Human, Mouse, Rat samples. Supplied as … WebPolyclonal Antibody for studying HIF1A. Cited in 194 publications. Validated for Western Blotting. Highly specific and rigorously validated in-house, HIF-1α Antibody (CST #3716) …
Web1 de mai. de 2024 · Specifically, we mimicked hypoxia pre-conditioning of MSCs via targeted editing of HIF1AN which showed improved therapeutic potential of MSCs. … Web24 de fev. de 2024 · Human papillomavirus-negative (HPV-neg) oropharyngeal squamous cell carcinomas (OPSCCs) are associated with poorer overall survival (OS) compared with HPV-positive (HPV-pos) OPSCCs. The major obstacle in improving outcomes of HPV-neg patients is the lack of robust biomarkers and therapeutic targets. Herein, we investigated …
Web21 de mar. de 2024 · Authors identified KANK3 as a new substrate for the oxygen sensor hypoxia-inducible factor 1-alpha inhibitor (HIF1AN), which hydroxylates HIF-1/2alpha …
Web22 de abr. de 2024 · Knockdown of HIF1AN also reversed the negatively regulation of circSLC8A1 on the biological functions of HKFs. Conclusion. Our data showed that circSLC8A1 regulates the miR-181a-5p/HIF1AN axis to restrain HKFs biological functions, confirming that circSLC8A1 might serve as a novel therapeutic target for keloids. images of page borders clip artWebBiological context of HIF1AN. This hydroxylation is performed by the novel asparaginyl hydroxylase, factor-inhibiting HIF-1 ' ( FIH-1 ), of which HIF-1alpha and HIF-2alpha are the only reported substrates [1]. FH and FIH-1 mutation analysis were performed by single stranded conformational polymorphism and direct sequencing of PCR products [2]. list of baby bondsWeb1 de fev. de 2003 · Pubmed ID Year Title Citations; 12080085: 2002: FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. images of pahWebHIF1AN (Hypoxia inducible factor 1 alpha inhibitor) is a corepressor that interacts with hypoxia inducible factor 1 (HIF1) alpha and the von Hippel Lindau tumor suppressor … images of paige butcherWebRabbit polyclonal HIF1AN/FIH-1 antibody. Validated in WB, IHC, ICC/IF and tested in Mouse, Human. Cited in 9 publication(s). Immunogen corresponding to recombinant full … images of pahrump nvWeb2 de fev. de 2024 · BackgroundHypoxia-inducible factor 1-alpha (HIF-1α) stability and transcriptional action are reduced by the hypoxia-inducible factor 1-alpha subunit … images of pagodasWeb2 de fev. de 2024 · Conclusions HIF1AN is a predictive indicator for breast tumors, and it is useful for predicting survival rates. Stratified by HIF1AN levels, different mRNA expression patterns in BC patients. images of pagham