Drak1
Web25 set 2014 · Subsequent medicinal chemistry work led to the discovery of a thieno[2,3-b]pyridine derivative with strong DRAK2 binding affinity (Kd = 9 nM). Moreover, this compound also behaves as a functional inhibitor of DRAK2 enzymatic activity, displaying an IC50 value of 0.82 μM, although lacking selectivity, when tested against DRAK1. Web30 nov 1998 · Overexpression of DRAK1 and DRAK2 induces the morphological changes associated with apoptosis. NIH 3T3 cells were co-transfected with expression vectors for DRAKs together with LacZ as an indicator of the transfection. After 36 h, transfected cells were visualized by staining with X-gal solution.
Drak1
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Web22 feb 2024 · Loss of DRAK1 protein is associated with paclitaxel resistance in cervical cancer cells. Although it is already known that NF-κB activation by anticancer agents … WebDRAK1 (STK17A) is a member of the DAP kinase-related apoptosis-inducing protein kinase family. DRAK1 encodes an autophosphorylated nuclear protein with a protein kinase domain which has apoptosis-inducing activity. DRAK1 is capable of autophosphorylation and of phosphorylating myosin light chain as an exogenous substrate.
Web19 set 2005 · DRAK1 and DRAK2 both contain strong consensus sequences for NLSs present near the kinase active site. DAPK3 and DAPK1 also contain such NLS motifs in this region, though DAPK1 is not normally localized in the nucleus as a result of retention by cytoskeletal proteins outside of this organelle ( 3 , 28 ). Web28 ott 2024 · DRAK1 inhibits the growth and metastasis of advanced cervical cancer cells through two pathways: interfering with the homo-oligomerization of tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) and specifically reducing the stability of TRAF6 protein through an autophagy-mediated degradation pathway (Park et al., 2024).
WebTNIK-IN-3 (compound 21k) inhibits Aurora-A, GCK, and MLK3 with IC 50 s of 0.517 μM, 3.657 μM, and 4.552 μM, respectively [1]. TNIK-IN-3 (0.1-100 μM; 3 days) inhibits the viability of HCT116 and DLD-1 cells, with IC 50 s of 4.26 μM and 8.00 μM, respectively [1]. TNIK-IN-3 (2.5-40 μM; 10 days) dose-dependently inhibits the colony formation of … Web22 feb 2024 · Furthermore, DRAK1 was markedly underexpressed in chemoresistant cervical cancer patient tissues compared with chemosensitive samples. We found that …
WebC Cell viability assay of DRAK1-knockdowned HeLa cells upon paclitaxel treatment ranging from 2.5 to 40 nM. The data represent the mean ± S.D. of three independent experiments. *p < 0.05; ...
WebDRAK1 (STK17A) is a member of the DAP kinase-related apoptosis-inducing protein kinase family. DRAK1 encodes an autophosphorylated nuclear protein with a protein kinase domain which has apoptosis-inducing activity. The DRAK1 (STK17A) Kinase Enzyme System can be purchased with or without the ADP-Glo™ Kinase Assay reagents. gleason gym videoWeb22 dic 2014 · DRAK1 is significantly overexpressed in HNSCC cells. (a) Heatmap of published microarray data sets of the expression levels of DRAK1 in normal and HNSCC … gleason h400WebDarrak1 streams live on Twitch! Check out their videos, sign up to chat, and join their community. gleason gymnastics open gymWebRecombinant full-length human DRAK1 (STK17A) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. DRAK1 (STK17A) is a member of the DAP … bodyguard 575 service manualWebRecombinant full-length human DRAK1 (STK17A) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. DRAK1 (STK17A) is a member of the DAP kinase-related apoptosis-inducing protein kinase family. DRAK1 encodes an autophosphorylated nuclear protein with a protein kinase domain which has apoptosis-inducing activity. bodyguard 575 pcaWeb22 feb 2024 · Furthermore, DRAK1 was markedly underexpressed in chemoresistant cervical cancer patient tissues compared with chemosensitive samples. We found that DRAK1 protein was destabilized through K48-linked polyubiquitination promoted by the Cullin scaffold protein 3 (CUL3) / speckle-type POZ (poxvirus and zinc finger protein) … gleason gymnastics portalWeb4 ott 2009 · A hardcore gang in tampa,florida that doesn't play with other foolish gangs or wanna be's.see tamp bay gleason hardware