WebDec 1, 2024 · Cisplatin and CasIIgly treatment had different effects on tumor cell metabolism. Cisplatin mainly affected phospholipid biosynthesis at the times established … WebFeb 9, 2001 · Our studies on STEALTH cisplatin show that NMR is a powerful tool in the characterization of drug-lipid interactions, the physical state of the drug inside the …
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WebFeb 1, 2012 · Cisplatin, 1, was used as purchased (Sigma-Aldrich, St. Louis, MO). Stock solutions of the platinum compounds in distilled water, 1 and 3, or DPBS (Dulbecco's phosphate buffered saline) buffer, 4, were in the range of 40–650 μM. WebNov 13, 2024 · H NMR-based metabolomics strategy was carried out, for the first time to our knowledge, to assess the impact of cisplatin on the metabolism of the kidney , adding the novel study of
WebFeb 18, 2024 · Furthermore, in order to elucidate the host-guest chemistry of the metallacages and the factors that favor cisplatin's retention in the supramolecular complexes, essential aspects to exploit the cages as drug delivery systems, the drug encapsulation was studied by 1 H, 1 H DOSY, and 195 Pt NMR spectroscopy under … WebOct 22, 2024 · NMR and LCMS analysis highlighted choline, creatine, phosphocholine, valine, acetic acid, phenylalanine, leucine, glutamic acid, threonine, uridine and proline …
WebHowever, like cisplatin and transplatin, only the cis isomer has anti-cancer activity, whereas the trans-isomer does not. ... The solution structure of the platinum-DNA adducts has been studied by two-dimensional NMR spectroscopy. Both the cis-platinum adducts and the trans-platinum adducts destabilize the DNA duplex significantly. The melting ... WebOct 22, 2024 · In NMR analysis, the effect of C. nutans aqueous extract against cisplatin on NRK-52E was quantitatively determined relative to the concentration of the internal reference standard, trimethylsilyl propionic acid (TSP). The concentration of the metabolites in NRK-52E cells extract and culture media of treated and non-treated groups and their ...
WebOct 16, 2013 · To monitor cisplatin-induced cell killing, a cell viability assay using ATPlite 1 Step kit (Perkin Elmer) was performed according to the manufacturer’s instructions followed by luminescence measurement …
WebNov 9, 2006 · The direct detection of 195Pt- and 15N-NMR signals was widely used in early studies of reactions of cis-diamminedichloroplatinum (II) (cis-DDP) with various … curly scarf knitting patternWebOct 3, 2013 · In this work, 1H high resolution magic angle spinning (HRMAS) nuclear magnetic resonance (NMR) spectroscopy was used to characterize the variations in the metabolome (small metabolites and mobile lipids) of A549 human lung cells in response to exposure to the alkylating drug cisplatin. Multivariate analysis and signal integration of … curly scentsWebMay 26, 2024 · Cisplatin is a well-known chemotherapeutic drug for solid tumors and leukemia with muscle toxicity, and long-term cisplatin medication can induce aberrant … curly scents instagramWebCisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck … curly scarf tutorialAntitumor agent cisplatin1 and its derivatives,2,3 when used alone or in combination with other chemotherapeutics4,5 can be effective against the advancement of several clinical cases of cancer. However, there are several known factors such as low selectivity, resistance and consequently, high toxicity that are … See more The calculations were carried out using the GAUSSIAN 09 package.34 The methodology used for the prediction of the NMR chemical shifts … See more In this work we used the relativistic NMR-DKH basis sets for the calculation of the 1H, 15N and 195Pt NMR spectra of inclusion complexes formed between cisplatin and … See more In this work we re-optimize the geometries of the molecular models of cDDP@CNTox or complex I (C168H24O15Cl2N2Pt) and cDDP@CNCox or … See more L. A. De Souza thanks the CAPES for a Post-Doctoral scholarship (Proc. No. 88882.306139/2024-01) during the period 2024–2024 at Universidade Federal Fluminense and support provided by Professor J. C. … See more curly scene hair tumblrWebOct 3, 2013 · Abstract. In this work, 1 H high resolution magic angle spinning (HRMAS) nuclear magnetic resonance (NMR) spectroscopy was used to characterize the … curly scarlet kaleWebOct 22, 2024 · In NMR analysis, the effect of C. nutans aqueous extract against cisplatin on NRK-52E was quantitatively determined relative to the concentration of the internal reference standard, trimethylsilyl propionic acid (TSP). The concentration of the metabolites in NRK-52E cells extract and culture media of treated and non-treated groups and their ... curlys cheese steaks menu